Supramolecular chemistry group

Mechanochemical Organic Synthesis. Mechanochemistry is an age-old technique that has received renewed interest in recent years due to its ability to carry out organic reactions with minimal or no solvent use, by milling and grinding solid reactants together. This reduced reliance on solvents decreases environmental impact, enhances safety, and improves cost-effectiveness, making it highly attractive for industrial applications. In addition to the benefits associated with green chemistry, mechanochemistry also significantly increases the reaction rates and reactivity of solids, including metals, helping to resolve long-standing challenges in organic synthesis. Our laboratory is dedicated to advancing organic synthesis through the incorporation of mechanochemical methods. This includes enhancing the synthesis and post-synthetic modifications of supramolecular receptor molecules and active pharmaceutical ingredients. We are also developing new mechanochemical synthetic methodologies that improve the performance of organic reactions by eliminating the use of solvents. Furthermore, we aim to facilitate the integration of mechanochemical processing into industrial manufacturing to enhance the circularity of scarce resources and materials. Our additional expertise includes assessing green chemistry metrics and the safety and impurity profiles of mechanochemical processes.